Sailing only along U.S. rivers and coastlines, American is the largest and most celebrated cruise line in the country.
As the season continues, American Cruise Lines will eventually run 16 unique itineraries throughout the region, exploring the Mississippi tributaries, including Tennessee, Ohio, Puget Sound, Columbia and Snake Rivers, Alaska and New England!
Free Airfare & Savings up to $1,500 on select dates.
Historic Mississippi River Cruise
New Orleans, LA to New Orleans, LA
8 Days / 7 Nights From $3,475
Sailing now through December 2026
Beginning and ending in the vibrant city of New Orleans, this incredible journey celebrates the rich heritage and festive spirit of a region where music is the common language and history can be found around every bend in the river.
Travel in the comfort of our new fleet as you discover fascinating port towns, including Natchez, with a unique blend of African, British, and French culture. As well as Baton Rouge, the heart and soul of Louisiana.
Savor authentic Cajun and Creole cuisine, embodying the influences of the fascinating people who live there. Explore elegant antebellum homes and notable landmarks brimming with history, led by a local guide who provides an insider’s perspective.
Back on board, be pampered by our gracious crew or find solace as you relax in your spacious stateroom and relish the rolling river views.
Sailing May 2024 thru October 2026
Memphis, TN to Nashville, TN
9 Days / 8 Nights From $3,720
Ask me about the Current Savings and a Pre-Cruise Package which include a premium hotel stay and transportation to the ship.
On this remarkable journey from Memphis to Nashville, experience the power of the Mississippi River, the grandeur of the Ohio River, and the beauty of the Cumberland River. Each waterway offers unique scenery with rolling hills, steep bluffs, soaring bald eagles, regal blue herons, fascinating historical sites, and sunsets reflecting on the water in indescribable beauty.
Discover the cities, small towns, along these legendary rivers that echo the sounds of the music that originated there. Enjoy diverse and immersive local excursions, as each day is a new delight through a parade of charming towns that echo a bygone era. Hear about the birthplace of blues and home to the King of Rock-n-Roll, from our onboard expert and local guides, who can provide a genuine back story about the performers who provided the soundtrack of America. Nightly onboard entertainment spotlights the musical flair of this region, as does an unforgettable visit to Nashville’s legendary Grand Ole Opry.
Enjoy a relaxing day cruising Lake Barkley and admire the most picturesque scenery in the American Heartland as you bask in the comfort of the most modern American Riverboat on the Mississippi. From large, wonderful windows and your private balcony, gaze at the everchanging views of the river valley and marvel at the ship’s transit through locks and dams.
At the end of an amazing day, indulge the flavors of the South and delight in a delicious beverage as you socialize at the daily cocktail hour.
Land and Cruise Package!
Great Smoky Mountains National Park
Knoxville, TN to Nashville, TN
12 Days / 11 Nights From $7,030
The beauty of the Tennessee River Valley is all-encompassing, framed by acres of forest, open plains, and the breathtaking Appalachian Mountain range. The river echoes with the music that was born there, in the iconic recording studios of Muscle Shoals where legends created songs that would become the soundtrack of America. Civil War battles were fought, and rockets were developed to send men to the moon in unassuming small towns along the shore. Be treated to the many treasures of the Tennessee River region, from exploring the capital of country music to tasting the world’s best whiskey.
Ridge upon ridge of forest straddles the border between North Carolina and Tennessee in Great Smoky Mountains National Park. Led by your Adventure Guide, explore America's most visited national park, world renowned for its diversity of plant and animal life, the beauty of its ancient mountains, and the quality of its remnants of Southern-Appalachian Mountain culture.
Sailing May 2024 thru October 2026
Chattanooga, TN to Nashville, TN
9 Days / 8 Nights From $3,720
On this cruise through the Tennessee Valley, admire the stunning natural backdrop as we pass through the Appalachian Mountains and the Land Between the Lakes. Experience the rich history and culture of the region on board our spectacular American riverboat. Renowned musicians will serenade you with a variety of music that was born of the river, as its banks were once home to a booming recording industry and the area was considered, “The Hit Recording Capital of the World.”
In Chattanooga, guests can explore local attractions such as the famous Walnut Street Pedestrian Bridge and Coolidge Park, accompanied by our expert local guides. You will also visit Savannah, the largest town on the Tennessee River and home to the nation's most well-preserved battlefield, Shiloh National Military Park.
Along with Civil War history, music-inspired cities, and incredible southern cuisine, you will cruise the Cumberland River through the Tennessee River Gorge and be amazed by the sights and sounds this region of the Mississippi has to offer.
Free Airfare & Savings up to $1,200
Lower Mississippi River Cruise
Memphis, TN to New Orleans, LA
9 Days / 8 Nights
From $3,720
Sailing now through December 2026
Ask me about the Current Savings and a Pre-Cruise package which include a premium hotel stay and transportation to the ship.
Embark on a unique riverboat adventure along the Lower Mississippi River between New Orleans, Louisiana and Memphis, Tennessee.
Savor a week aboard our intimate and relaxed modern riverboat with 180 guests or fewer. Our enthusiastic all-American crew is ready to share with you a wonderful journey filled with historical tales, culinary delights, vibrant music, and new friends.
Dynamic presentations by your onboard speaker connect you to the region’s culture and history, while local guides share insights to illuminate your shore excursions. New Orleans reverberates with the sounds of jazz, while Memphis offers savory barbecue, rich music history museums, and an amazing exploration of Elvis’ Graceland. Discover why the Mississippi River and the port of Vicksburg were so important during the Civil War and enjoy the beautiful architecture, antiques, and gardens of grand estates alongside the river, including Houmas House, and Rosedown. Perhaps sip and savor a tasty mint julep while strolling under the canopy of 300-year-old trees at Oak Alley or peruse the local shops and museums of quaint and cozy towns like St. Francisville and Natchez.
Back aboard your riverboat, relax with our daily cocktail hour, hors d'oeuvres, a delicious meal, and an evening show as regional entertainers share the area’s renowned cultural flair.
Sailing now through October 2026
Upper Mississippi River Cruise
St. Louis, MO to St. Paul, MN
9 Days / 8 Nights From $4,530
Ask me about the Current Savings and a Pre-Cruise package which include a premium hotel stay and transportation to the ship.
A journey along the Upper Mississippi River is an enriching experience, embodying hometown Americana and the breathtaking scenery that has inspired the country’s most legendary writers, artists, and musicians. It was here that the great American writer Mark Twain used the majestic river and its scenic bluffs as the settings in his most popular works. In his book “Life on the Mississippi,” he described traveling on this part of the river as “always through enchanting scenery, there being no other kind on the Upper Mississippi.” Visit his boyhood home in Hannibal, where the characters of Huck Finn, Tom Sawyer, and Becky Thatcher come to life.
Explore the beautiful gardens and historic homes of the region in the company of our carefully selected expert guides. From your private balcony, admire stretches of undeveloped countryside, ornamented with pelicans, soaring eagles, and blue herons. Weave among hundreds of picturesque islands and through the amazing engineering of dams and navigation locks.
Along the way, be treated to the gracious hospitality of our crew and savor an exquisite menu, featuring dishes masterfully prepared by our culinary team, with a dash of local flavor.
Just as it was back in Mark Twain’s day, every riverboat on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.
See below for current special offers on amazing itineraries and packages
Free Airfare and Savings up to $1,200
Spend this in the Intracoastal Waterway, home to some of the most beautiful historic cities in America, is a protected network of bays, rivers, and canals. Start your journey in Charleston, lined with cobblestone streets and antebellum houses, and where the first shots of the Civil War were heard. For a limited time, you can set sail on the brand-new American Eagle and receive
Free Airfare & Savings up to $2,000
Spend this summer exploring New England on our Grand New England Cruise. On this epic journey, travel along the picturesque waterways of New England that tell the story of American history, from the Mayflower’s landing to the Boston Tea Party. A centuries-old shipbuilding tradition lives on here in shipyards along the shoreline and schooners that adorn the harbors. Set sail on 7/1 or 7/15 and receive free Airfare & Savings up to $2,000.